Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

330
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
330
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

307
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
307
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

245
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
245
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

274
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
274
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

104.0K
Overview
104.0K
Conservation of Small Populations02:04

Conservation of Small Populations

17.4K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent Substance Use Screening in the Emergency Department.

Journal of the American College of Emergency Physicians open·2026
Same author

A Quality Improvement Project to Increase Nurse-initiated Care from Triage and Improve Timeliness to Care in the Pediatric Emergency Department.

Pediatric quality & safety·2026
Same author

Effective Community Consultation for Prehospital EFIC Research: Lessons from a 20-Site Pediatric Trial.

Prehospital emergency care·2026
Same author

Challenges to Caring for Injured Children With Special Health Care Needs in Emergency Settings.

Hospital pediatrics·2026
Same author

Pediatric Readiness in the Emergency Department: Policy Statement.

Journal of the American College of Surgeons·2026
Same author

Pediatric Readiness in the Emergency Department: Policy Statement.

Journal of emergency nursing·2026

Related Experiment Video

Updated: Feb 10, 2026

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.6K

Priorities for pediatric prehospital research.

George L Foltin1, Peter Dayan, Michael Tunik

  • 1Department of Pediatrics, Division of Pediatric Emergency Medicine, Bellevue Hospital Center, New York University School of Medicine, New York, NY, USA. gf16@nyu.edu

Pediatric Emergency Care
|October 9, 2010
PubMed
Summary

Emergency medical services (EMS) research for children is limited. The Pediatric Emergency Care Applied Research Network (PECARN) developed a prioritized research agenda for pediatric prehospital care, focusing on clinical and system topics.

More Related Videos

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

13.5K
Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.4K

Related Experiment Videos

Last Updated: Feb 10, 2026

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

4.6K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

13.5K
Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.4K

Area of Science:

  • Pediatric Emergency Medicine
  • Prehospital Care Research
  • Health Services Research

Background:

  • Limited research exists on pediatric prehospital care, despite millions of US children annually receiving care from emergency medical services (EMS).
  • The Pediatric Emergency Care Applied Research Network (PECARN) aims to advance high-quality research for children, including in the prehospital setting.

Framework:

  • A 3-step consensus-driven process was employed to develop a pediatric-specific prehospital research agenda.
  • Participants ranked and scored potential research priorities using a modified Hanlon method, assessing prevalence, seriousness, and practicality.

Implementation:

  • Forty-two representatives from PECARN nodes, EMS agencies, and prehospital research fields participated.
  • A revised priority list was presented at a PECARN EMS summit to achieve consensus.

Implications:

  • Consensus was reached, yielding ranked lists of 15 clinical and 5 EMS system research topics.
  • The identified priorities, including airway management, respiratory distress, and trauma, will guide future pediatric prehospital research within and beyond PECARN.