Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Selective retinal therapy with microsecond exposures using a continuous line scanning laser.

Yannis M Paulus1, Atul Jain, Hiroyuki Nomoto

  • 1Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA. ypaulus@stanford.edu

Retina (Philadelphia, Pa.)
|October 9, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Summary of Research: Aflibercept 8 mg versus Faricimab Treat‑and‑Extend for Diabetic Macular Edema or Neovascular Age‑Related Macular Degeneration: A Bayesian Fixed‑Effect Network Meta‑analysis of Clinical Trials.

Ophthalmology and therapy·2026
Same author

Multi-OCT-SelfNet: integrating self-supervised learning with multi-source data fusion for enhanced multi-class retinal disease classification.

Frontiers in systems biology·2026
Same author

Histological findings after subretinal implantation of the PRIMA photovoltaic array in patients with geographic atrophy due to AMD.

Ophthalmology. Retina·2026
Same author

Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study.

Ophthalmology·2026
Same author

Residual photoreceptors affect the response of a degenerate retina to electrical stimulation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A Simplified Classification for Age-Related Macular Degeneration Based on Optical Coherence Tomography.

Ophthalmic surgery, lasers & imaging retina·2026

Continuous scanning laser therapy safely and selectively targets retinal pigment epithelium and photoreceptors, promoting healing without scarring. This fast laser technology enables efficient treatment of large retinal areas.

Area of Science:

  • Ophthalmology
  • Retinal Laser Therapy
  • Biomedical Optics

Background:

  • Traditional laser photocoagulation can cause collateral damage.
  • Developing precise retinal treatment methods is crucial for preserving vision.

Purpose of the Study:

  • To assess the safety, selectivity, and healing characteristics of retinal lesions produced by a continuous line scanning laser.
  • To determine the efficacy of this novel laser system for retinal therapy.

Main Methods:

  • A 532-nm Nd:YAG continuous scanning laser (PASCAL) was used on rabbit eyes.
  • Varying beam diameters (40 μm, 66 μm) and exposure durations (15–60 μs) were tested.
  • Lesion assessment included ophthalmoscopy, fluorescein angiography, RPE flatmounts, and histology over two months.

More Related Videos

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
11:03

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Main Results:

  • Safety and selectivity improved with shorter durations and smaller beam diameters.
  • Fluorescein angiography and live-dead assays showed comparable retinal pigment epithelial (RPE) damage thresholds.
  • Histology revealed focal RPE and photoreceptor damage, with complete healing by one month, and no inner retinal damage.

Conclusions:

  • Continuous scanning laser therapy selectively targets RPE and photoreceptors.
  • The treatment promotes rapid healing without permanent scarring or inner retinal damage.
  • This technology allows for rapid treatment of extensive retinal areas within clinical timeframes.