Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms.

Stem cell reports·2026
Same author

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty-Related Limitation in Maintenance Hemodialysis Patients: A Cross-Sectional Study.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2026
Same author

Association between blood mitochondrial DNA copy number and cognitive function: A cross-sectional study based on the Yakumo Study.

Fujita medical journal·2026
Same author

Induction of oxidative stress-associated cell death in HepG2 cells by combined methylmercury and palmitic acid exposure at low non-toxic concentrations.

Bioscience, biotechnology, and biochemistry·2026
Same author

Jcvrisk: An R Package for Population-level Estimation of Cardiovascular Risk Scores in Japanese Adults.

Journal of epidemiology·2025
Same author

Myonectin stimulates endothelial angiogenic activity in vitro and in vivo.

Nagoya journal of medical science·2025

Related Experiment Video

Updated: Jun 8, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Adiponectin and hypertension.

Koji Ohashi1, Noriyuki Ouchi, Yuji Matsuzawa

  • 1Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, Japan.

American Journal of Hypertension
|October 9, 2010
PubMed
Summary
This summary is machine-generated.

Obesity lowers adiponectin, a protective adipokine. This review explores adiponectin's role in regulating blood pressure and vascular health, offering insights into cardiovascular disease prevention.

More Related Videos

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Adipose Tissue Biology

Background:

  • Adipose tissue releases bioactive adipokines.
  • Obesity, especially visceral fat, dysregulates adipokine secretion, contributing to metabolic syndrome and cardiovascular diseases.
  • Adiponectin, an adipose-specific adipokine, is reduced in obesity and offers protective effects against related complications.

Purpose of the Study:

  • To review clinical and experimental evidence on adiponectin's role in hypertension.
  • To examine adiponectin's function in regulating vascular health.
  • To elucidate adiponectin's mechanisms in preventing vascular disorders.

Main Methods:

  • Review of clinical studies investigating adiponectin levels and cardiovascular outcomes.
  • Analysis of experimental research on adiponectin's direct effects on vascular components.
  • Synthesis of findings on adiponectin's impact on hypertension and vascular function.

Main Results:

  • Reduced plasma adiponectin levels correlate with obesity and visceral fat accumulation.
  • Adiponectin demonstrates protective properties against hypertension, metabolic dysfunction, atherosclerosis, and ischemic heart disease.
  • Adiponectin directly influences vascular tissue components to exert beneficial effects.

Conclusions:

  • Adiponectin plays a crucial role in maintaining vascular health and regulating blood pressure.
  • Therapeutic strategies targeting adiponectin may offer potential for managing obesity-related cardiovascular complications.
  • Further research into adiponectin's mechanisms can inform the development of novel treatments for hypertension and vascular disease.