MAPK signalling in cellular metabolism: stress or wellness?
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Updated: Jun 8, 2026

Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment
Published on: September 25, 2017
Helmuth Gehart1, Susann Kumpf, Arne Ittner
1Department of Biology, Institute of Cell Biology, ETH Zurich, Hönggerberg Campus, Switzerland.
Abstract:
Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intracellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.
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