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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Left ventricular diastolic function in a predialysis patient population

E B Arodiwe1, I I Ulasi, C K Ijoma

  • 1Renal Unit, University of Nigeria Teaching Hospital, Enugu, Nigeria. arodiwenephrol@yahoo.com

West African Journal of Medicine
|October 9, 2010
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is highly prevalent in Nigerian chronic kidney disease (CKD) patients. Age was identified as the sole predictor of LVDD in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Echocardiography

Background:

  • Diastolic dysfunction is a frequent complication in chronic kidney disease (CKD), affecting 40%-66% of patients.
  • Understanding the prevalence and contributing factors of left ventricular diastolic dysfunction (LVDD) in CKD is crucial for cardiovascular risk management.

Purpose of the Study:

  • To determine the prevalence of LVDD in adult Nigerians with CKD.
  • To identify factors associated with LVDD in CKD patients.
  • To compare LVDD findings in CKD patients with those in hypertensive patients with normal renal function.

Main Methods:

  • A study involving 86 consecutive CKD patients, including 43 hypertensives and 43 age/sex-matched healthy controls.
  • Collection of clinical, laboratory, and echocardiographic data.
  • Analysis of left ventricular diastolic function (LVDF) in relation to various clinical parameters.

Main Results:

  • LVDD was observed in 62.8% of CKD patients, 79.1% of hypertensive patients, and 25.6% of controls (p<0.001).
  • In CKD patients, LVDF correlated positively with blood pressure parameters but negatively with age.
  • Age emerged as the only significant predictor of LVDD through linear multiple regression analysis.

Conclusions:

  • A high prevalence of diastolic dysfunction exists in Nigerian CKD patients upon initial nephrology consultation.
  • These findings underscore the importance of assessing diastolic function in CKD patients early in their disease course.
Abstract

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