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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Related Experiment Video

Updated: Jun 8, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Left ventricular diastolic function in a predialysis patient population.

E B Arodiwe1, I I Ulasi, C K Ijoma

  • 1Renal Unit, University of Nigeria Teaching Hospital, Enugu, Nigeria. arodiwenephrol@yahoo.com

West African Journal of Medicine
|October 9, 2010
PubMed
Summary

Left ventricular diastolic dysfunction (LVDD) is highly prevalent in Nigerian chronic kidney disease (CKD) patients. Age was identified as the sole predictor of LVDD in this population.

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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Area of Science:

  • Cardiology
  • Nephrology
  • Echocardiography

Background:

  • Diastolic dysfunction is a frequent complication in chronic kidney disease (CKD), affecting 40%-66% of patients.
  • Understanding the prevalence and contributing factors of left ventricular diastolic dysfunction (LVDD) in CKD is crucial for cardiovascular risk management.

Purpose of the Study:

  • To determine the prevalence of LVDD in adult Nigerians with CKD.
  • To identify factors associated with LVDD in CKD patients.
  • To compare LVDD findings in CKD patients with those in hypertensive patients with normal renal function.

Main Methods:

  • A study involving 86 consecutive CKD patients, including 43 hypertensives and 43 age/sex-matched healthy controls.
  • Collection of clinical, laboratory, and echocardiographic data.
  • Analysis of left ventricular diastolic function (LVDF) in relation to various clinical parameters.

Main Results:

  • LVDD was observed in 62.8% of CKD patients, 79.1% of hypertensive patients, and 25.6% of controls (p<0.001).
  • In CKD patients, LVDF correlated positively with blood pressure parameters but negatively with age.
  • Age emerged as the only significant predictor of LVDD through linear multiple regression analysis.

Conclusions:

  • A high prevalence of diastolic dysfunction exists in Nigerian CKD patients upon initial nephrology consultation.
  • These findings underscore the importance of assessing diastolic function in CKD patients early in their disease course.