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Related Experiment Video

Updated: Jun 8, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Immunonutrition in gastrointestinal surgery.

Y Cerantola¹, M Hübner, F Grass

¹Department of Visceral Surgery, University Hospital Vaudois (CHUV), Bugnon 46, 1011 Lausanne, Switzerland.

The British Journal of Surgery

|October 9, 2010

Summary

This summary is machine-generated.

Perioperative immunonutrition (IN) significantly reduces complications and hospital stay for major gastrointestinal surgery patients. However, this meta-analysis found no impact on mortality, supporting routine IN use.

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Murine Ileocolic Bowel Resection with Primary Anastomosis

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Published on: October 29, 2014

Area of Science:

Clinical Nutrition
Surgical Gastroenterology
Evidence-Based Medicine

Background:

Major gastrointestinal surgery poses significant complication risks.
Immunonutrition (IN) use is limited due to heterogeneous and contradictory data on its effectiveness.

Purpose of the Study:

To systematically evaluate the clinical impact of perioperative enteral immunonutrition (IN) in major gastrointestinal surgery.
To clarify the effects of IN on complications, mortality, and hospital stay.

Main Methods:

A meta-analysis of randomized controlled trials (RCTs) published between 1985 and 2009.
Included 21 RCTs with 2730 patients undergoing elective major gastrointestinal surgery.

Main Results:

IN significantly reduced overall complications and postoperative infections across different administration timings.
Perioperative IN led to a significant reduction in hospital stay by an average of 2.12 days.
No significant effect of IN on patient mortality was observed.

Conclusions:

Perioperative enteral IN effectively decreases morbidity and shortens hospital stay after major gastrointestinal surgery.
The routine use of perioperative IN is recommended for patients undergoing major gastrointestinal surgery.
Immunonutrition does not influence mortality rates in this patient population.