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Azadirachtin poisoning: a case report
Ramya Iyyadurai1, V Surekha, Sowmya Sathyendra
1Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India. iramya@cmcvellore.ac.in
Clinical Toxicology (Philadelphia, Pa.)
|October 12, 2010
Summary
Neem pesticide overdose can cause neurotoxicity requiring intensive care. This case report highlights that adults can recover from Azadirachtin poisoning with proper medical support.
Area of Science:
- Toxicology
- Environmental Health
- Pharmacology
Background:
- Neem-based pesticides are widely used in the Indian Subcontinent and are generally perceived as safe natural alternatives.
- Limited literature exists on the toxic effects of adult ingestion and overdose of neem-based pesticides, particularly Azadirachtin.
Observation:
- A case of a 35-year-old female who intentionally ingested a large dose of Azadirachtin was reported.
- The patient presented with significant neurotoxicity symptoms, necessitating intensive medical care and mechanical ventilation.
Findings:
- Azadirachtin overdose in adults can lead to severe neurotoxicity.
- Prompt and intensive medical intervention, including mechanical ventilation, was crucial for the patient's survival.
Implications:
- This case underscores the potential neurotoxic risks associated with Azadirachtin, even from a natural source.
- It highlights the importance of recognizing and managing Azadirachtin poisoning in clinical toxicology settings.
- Further research into the toxicological profile and safe dosage limits of neem-based products is warranted.
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