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Potentiation of cisplatin lethality by bacterial lipopolysaccharide pretreatment in mice
M Ishikawa1, R Ohzeki, Y Takayanagi
1Department of Pharmacology & Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|December 1, 1990
Abstract:
The present study was designed to determine whether bacterial endotoxin (LPS) affects the lethality of cisplatin. Mice treated with LPS (1 mg/kg, i.p.) 24 hr and 1 hr before cisplatin had markedly increased the lethality and nephrotoxicity of cisplatin.