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Related Experiment Video

Updated: Jun 8, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPV1 function in health and disease.

John P M White¹, Laszlo Urban, Istvan Nagy

¹Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK.

Current Pharmaceutical Biotechnology

|October 12, 2010

Summary

The transient receptor potential vanilloid type 1 (TRPV1) channel causes burning pain from heat and capsaicin. Its widespread roles in various bodily functions present therapeutic challenges and opportunities.

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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Published on: December 31, 2013

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

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Published on: September 2, 2020

Area of Science:

Neuroscience
Molecular Biology
Physiology

Background:

Transient receptor potential vanilloid type 1 (TRPV1) ion channels are known mediators of heat and capsaicin-induced burning pain.
TRPV1 plays a critical role in inflammatory pain signaling in peripheral tissues.
Recent discoveries reveal TRPV1's presence across diverse anatomical locations.

Purpose of the Study:

To review the expanding functions of TRPV1 in both physiological and pathological conditions.
To explore TRPV1's involvement beyond pain, including its roles in homeostasis and disease.
To discuss the therapeutic potential and challenges associated with targeting TRPV1.

Main Methods:

Literature review of recent scientific findings on TRPV1.
Analysis of studies investigating TRPV1 expression and function.
Synthesis of information regarding TRPV1's role in various organ systems and diseases.

Main Results:

TRPV1 is expressed widely throughout the human body, suggesting diverse functions.
Beyond pain, TRPV1 is implicated in urinary tract, respiratory, and auditory systems.
TRPV1 involvement extends to homeostasis, metabolism, hair growth, and cancer development.

Conclusions:

TRPV1's multifaceted roles indicate significant potential for therapeutic interventions.
The widespread distribution of TRPV1 complicates targeted drug development due to potential off-target effects.
Further research is needed to harness TRPV1's therapeutic benefits while mitigating risks.