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Combating evolution with intelligent design: the neoglycoside ACHN-490.

Eliana S Armstrong¹, George H Miller

¹Achaogen Inc., 7000 Shoreline Court, Suite 372, South San Francisco, CA 94080, USA.

Current Opinion in Microbiology

|October 12, 2010

Summary

ACHN-490, a novel neoglycoside antibiotic, shows promising activity against drug-resistant bacteria. Early studies suggest it could be a vital new agent to combat rising antimicrobial resistance.

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Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection

Design and Use of a Low Cost, Automated Morbidostat for Adaptive Evolution of Bacteria Under Antibiotic Drug Selection

Published on: September 27, 2016

Area of Science:

Microbiology
Pharmacology
Infectious Diseases

Background:

Rising global antimicrobial resistance presents a significant public health challenge.
Existing antibiotic strategies require enhancement, alongside the development of novel antimicrobial agents.
Gram-negative organisms and antibiotic-resistant strains are key targets for new therapeutic development.

Purpose of the Study:

To introduce ACHN-490, the first neoglycoside antibiotic, into clinical development.
To evaluate the potential of ACHN-490 in addressing the unmet need for new antibacterial drugs.
To assess ACHN-490's efficacy against key bacterial pathogens, including resistant strains.

Main Methods:

In vitro assessment of ACHN-490's activity against wild-type and resistant bacterial strains.
Evaluation of ACHN-490's bactericidal and synergistic properties.
Review of Phase 1 clinical study results for ACHN-490 injection.

Main Results:

ACHN-490 demonstrated promising in vitro activity against a range of bacteria.
The compound showed efficacy against both wild-type and drug-resistant bacterial isolates.
ACHN-490 retains favorable bactericidal and synergistic characteristics of aminoglycosides.

Conclusions:

ACHN-490 represents a promising next-generation aminoglycoside antibiotic.
Clinical development of ACHN-490 offers potential for a new therapeutic option against resistant infections.
Early data suggest ACHN-490 could help meet the urgent need for novel antibacterial agents.