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Related Concept Videos

Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...

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Updated: Jun 8, 2026

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome
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"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome

Published on: March 24, 2023

Towards a comprehensive human cell-surface immunome database.

M Carmen Díaz-Ramos1, Pablo Engel, Ricardo Bastos

  • 1Institut d'investigacions Biomèdiques Agust Pi i Sunyer (IDIBAPS), Dept. of Cell Biology, Immunology and Neurosciences, University of Barcelona, Spain.

Immunology Letters
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

Researchers created a comprehensive database of human cell-surface proteins on immune cells. This resource catalogs 1015 proteins, aiding the discovery of new diagnostic and therapeutic targets for immune system research.

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Area of Science:

  • Immunology
  • Proteomics
  • Bioinformatics

Background:

  • Cell-surface proteins on immune cells are crucial for immune response regulation.
  • These proteins represent key targets for diagnostics and therapeutics.
  • A centralized, curated database is needed to consolidate this information.

Purpose of the Study:

  • To develop a comprehensive database of human cell-surface proteins expressed in immune cells and lymphoid tissues.
  • To integrate data from literature, databases, and electronic sources.
  • To provide detailed information including gene symbol, protein name, family, extracellular domains, and expression data.

Main Methods:

  • Manual curation of information from diverse sources.
  • Integration of data including gene symbol, protein name, family classification, extracellular domain type, and expression.
  • Cataloging of identified genes and proteins.

Main Results:

  • Identified and cataloged 1015 genes and proteins.
  • The largest protein families are the Immunoglobulin (Ig) superfamily (195 members) and G-protein coupled receptors (147 members).
  • Over 60% of genes encode proteins lacking a Cluster of Differentiation (CD) number, highlighting novel targets.

Conclusions:

  • The database provides a valuable resource for immune system research.
  • It will facilitate the development of new monoclonal antibodies.
  • The findings will stimulate research into protein function, biomarkers, and therapeutic targets within the immune system.