Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy
05:02

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Injectable hydrogel scaffold from decellularized human lipoaspirate.

D Adam Young1, Dina O Ibrahim, Diane Hu

  • 1Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.

Acta Biomaterialia
|October 12, 2010
PubMed
Summary

Researchers created an injectable adipose matrix scaffold from human fat tissue. This novel hydrogel supports cell growth and offers a minimally invasive option for adipose tissue engineering.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Reconstruction of Deep Partial-Thickness Burns With Ovine Forestomach Matrix: Results From a Prospective Observational Study.

Cureus·2026
Same author

Age-related Delays in Osteochondral Remodeling of Fracture Healing Illustrated by Mass Spectrometry Imaging.

bioRxiv : the preprint server for biology·2026
Same author

Vascularized tissue coverage of trauma and acute care surgery defects with ovine forestomach matrix: interim results of a prospective multicenter study.

Journal of trauma and injury·2026
Same author

Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction.

Advanced healthcare materials·2025
Same author

Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction.

bioRxiv : the preprint server for biology·2025

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Soft tissue fillers are popular for aesthetic and reconstructive purposes.
  • Existing fillers often resorb quickly and fail to mimic native adipose extracellular matrix (ECM).

Purpose of the Study:

  • To develop an injectable adipose matrix scaffold that overcomes limitations of current soft tissue fillers.
  • To create a biomaterial that supports adipogenesis and mimics native adipose ECM.

Main Methods:

  • Human lipoaspirate was decellularized to remove cellular and lipid components, preserving ECM.
  • The decellularized ECM was solubilized to create a thermally responsive hydrogel.
  • Patient-matched adipose-derived stem cells were cultured with the hydrogel in vitro.

More Related Videos

Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation
05:42

Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation

Published on: April 5, 2024

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Related Experiment Videos

Last Updated: Jun 8, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy
05:02

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation
05:42

Three-Dimensional Cell Culture of Adipose-Derived Stem Cells in a Hydrogel with Photobiomodulation Augmentation

Published on: April 5, 2024

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Main Results:

  • The decellularized adipose matrix retained native ECM composition, including peptides and glycosaminoglycans.
  • The hydrogel self-assembled upon subcutaneous injection and supported adipose-derived stem cell growth and survival.
  • This approach offers a minimally invasive method for adipose tissue engineering.

Conclusions:

  • An injectable hydrogel derived from human lipoaspirate represents a promising scaffold for adipose tissue engineering.
  • The developed hydrogel mimics native adipose ECM and supports cell viability, addressing limitations of current fillers.
  • This technology provides a minimally invasive solution for both source material collection and scaffold delivery.