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A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
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Design and evaluation of a novel formulation prediction system

Jin Guan1, Rongwu Xiang, Yusheng Pan

  • 1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Liaoning, Shenyang 110016, China.

International Journal of Pharmaceutics
|October 12, 2010
PubMed
Summary

A new formulation prediction system aids in monolithic osmotic pump tablet (MOPT) development. This system, using ternary-component diagrams, improves experiment efficiency and predicts optimal MOPT formulations.

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