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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

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Updated: Jun 8, 2026

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils
08:14

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils

Published on: November 11, 2025

[Neutrophilic dermatoses].

B Soutou1, D Vignon-Pennamen, O Chosidow

  • 1Centre hospitalier du Nord, 100, Jdeidet, Zgharta, Liban.

La Revue De Medecine Interne
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

Neutrophilic dermatoses involve skin inflammation from neutrophil infiltration without infection. Treatment varies from corticosteroids for severe cases to colchicine or dapsone for milder presentations.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Context:

  • Neutrophilic dermatoses represent a group of inflammatory skin conditions characterized by neutrophil infiltration.
  • Conditions like Sweet's syndrome and pyoderma gangrenosum fall under this spectrum.
  • These disorders can present atypically or as overlapping syndromes.

Purpose:

  • To provide a comprehensive overview of neutrophilic dermatoses.
  • To discuss the classification, clinical presentation, and systemic associations of these conditions.
  • To outline current therapeutic strategies based on disease severity and form.

Summary:

  • Neutrophilic dermatoses are skin inflammatory disorders with neutrophil infiltration, lacking infection.
  • Classified into superficial, en plaques, and deep forms based on infiltrate location.
  • Frequently associated with systemic diseases like hematologic malignancies, IBD, and autoimmune disorders.
  • Treatment modalities range from systemic corticosteroids for severe acute forms to colchicine, dapsone, or topical steroids for milder or chronic presentations.

Impact:

  • Enhances understanding of neutrophilic dermatoses for clinicians and researchers.
  • Highlights the importance of recognizing systemic associations for comprehensive patient management.
  • Informs treatment decisions by detailing therapeutic options for various disease presentations.