[Quantitative studies on nuclear DNA content and morphological features in inverted papillomas of the nasal cavities...

DNA contents and morphological features (including nuclear area, nuclear perimeter and nuclear volume) were quantitatively measured by image analysis in 38 inverted papillomas (IP) of the nasal cavities and paranasal sinuses. Results showed that DNA contents and morphological parameters increased markedly than those of the normal cells, but were lower than those of malignant cells, indicating IP may be a borderline tumor in proliferative state. There was significant correlation between the DNA ploidy and recurrence rate of IP, aneuploid tumors have a higher recurrence rate than diploid and multi-euploid tumors. Quantitative measurements of DNA contents and morphological parameters very important for early detection of recurrence and malignant change in IP.