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Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: synthesis and antitumoral activities

Maria-João R P Queiroz1, Ricardo C Calhelha, Luís A Vale-Silva

  • 1Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. mjrpq@quimica.uminho.pt

European Journal of Medicinal Chemistry
|October 12, 2010
PubMed

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Basicity of Heterocyclic Aromatic Amines

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Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
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