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Association of Budd-Chiari syndrome and celiac disease

N Afredj1, S Metatla, S A Faraoun

  • 1Service d'hépato-gastroentérologie, CHU Mustapha, Alger, Algeria. afnawel@yahoo.fr

Gastroenterologie Clinique Et Biologique
|October 12, 2010
PubMed

Insights

The study found a frequent association between Budd-Chiari syndrome (BCS) and celiac disease (CD), with CD potentially contributing to thrombosis in over half of cases. Specific HLA alleles were linked to CD but not the BCS-CD association.

Area of Science:

  • Gastroenterology
  • Hematology
  • Immunology

Background:

  • Budd-Chiari syndrome (BCS) and celiac disease (CD) association is considered uncommon.
  • Investigating the etiology of BCS and identifying specific HLA antigen patterns in patients with CD is crucial.

Purpose of the Study:

  • To explore the link between Budd-Chiari syndrome and celiac disease.
  • To identify potential etiological factors for BCS in celiac patients.
  • To investigate HLA antigen patterns in patients with BCS and CD.

Main Methods:

  • Diagnosis of BCS using Doppler ultrasound and CD via duodenal biopsy, transglutaminase (TGAb), and gliadin antibodies (GAb).
  • Screening for prothrombotic disorders and HLA genotyping using PCR-SSO.
  • Treatment involved anticoagulants and a gluten-free diet.

Main Results:

  • Nine patients (mean age 27, F/M ratio 2) with BCS and CD were studied.
  • All patients exhibited endoscopic and histological signs of CD; 78% tested positive for GAb/TGAb.
  • Commonly found HLA alleles were HLA DQβ1(*)02 (6 patients) and DQβ1(*)03 (3 patients).
  • Prothrombotic conditions were identified in 4 patients, while 5 had no identifiable prothrombotic state.

Conclusions:

  • The association between BCS and CD appears more frequent than previously thought.
  • In over 50% of cases, no underlying prothrombotic conditions were found, suggesting CD's role in thrombosis.
  • Identified HLA alleles are strongly associated with CD, but no specific pattern was observed for the BCS-CD association.
Abstract

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