Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

Dopexamine Test in septic shock with hyperlactatemia.

N Mayeur1, F Vallée, O De Soyres

  • 1GRCB 48, IFR 150, unité de réanimation polyvalente de Purpan, pôle d'anesthésie et réanimation, CHU de Toulouse, université Paul-Sabatier, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France. nicolas.mayeur@inserm.fr

Annales Francaises D'Anesthesie Et De Reanimation
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endometriosis and breakthrough pain during labor epidural analgesia: a matched case-control study 2025-2026.

International journal of obstetric anesthesia·2026
Same author

Circulating dipeptidyl peptidase 3 and outcomes in acute heart failure: an analysis of the STRONG-HF and CORTAHF studies.

ESC heart failure·2026
Same author

Factors associated with severe pain during the active phase of pushing despite labor epidural analgesia: a secondary analysis on a prospective cohort study.

International journal of obstetric anesthesia·2025
Same author

Impact of Dyslipidemia, Cardiovascular Disease, Smoking, and Stroke Type by Brain Imaging on Pneumonia Risk in ICU Stroke Patients: A Cross-Sectional Observational Study.

La Clinica terapeutica·2025
Same author

Factors associated with breakthrough pain with labor epidural analgesia: a single-center prospective study.

International journal of obstetric anesthesia·2025
Same author

Predictors of repeat epidural blood patch for postdural puncture headache after labor epidural analgesia: a single-center retrospective cohort study (2014-2024).

International journal of obstetric anesthesia·2025

Dopexamine (DPX) decreased lactate levels in 52% of septic shock patients. A 14% increase in mean arterial pressure (MAP) within 30 minutes predicted lactate clearance, suggesting DPX may improve outcomes in persistent hyperlactatemia.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Hemodynamics

Background:

  • Septic shock with persistent hyperlactatemia poses a significant clinical challenge.
  • High-dose norepinephrine (NE) is often required, but may not fully resolve circulatory dysfunction.
  • Dopexamine (DPX), a dopamine agonist, has potential inotropic and vasodilatory effects.

Purpose of the Study:

  • To evaluate the 6-hour hemodynamic effects of dopexamine (DPX) infusion in septic shock patients with persistent hyperlactatemia.
  • To assess the impact of DPX on lactate clearance and norepinephrine requirements.
  • To identify predictors of response to DPX therapy.

Main Methods:

  • Preliminary, prospective, uncontrolled study involving 21 septic shock patients.
  • Patients received DPX infusion (0.5 μg/kg/min) alongside high-dose NE.

More Related Videos

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
09:34

The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells

Published on: July 27, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
09:34

The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells

Published on: July 27, 2018

  • Response was defined as a ≥20% decrease in lactatemia after 6 hours.

    • Main Results:

    • 52% of patients were classified as DPX-responders.
    • DPX-responders showed a significantly greater increase in mean arterial pressure (MAP) at 30 minutes compared to non-responders.
    • An increase in MAP >14% within 30 minutes predicted lactate clearance with high sensitivity and specificity.
    • DPX responders had reduced NE requirements and significantly lower 28-day mortality (7% vs. 90%).

    Conclusions:

    • DPX infusion decreased lactatemia in 52% of septic shock patients.
    • Early increase in MAP (>14% within 30 minutes) may predict successful lactate clearance with DPX.
    • Further controlled studies are warranted to confirm these preliminary findings and the role of DPX in septic shock management.