Related Experiment Video
Updated: Jun 8, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
Published on: May 6, 2009
The roles of thiol oxidoreductases in yeast replicative aging
Elise Hacioglu1, Isil Esmer, Dmitri E Fomenko
1Izmir Institute of Technology, Department of Molecular Biology and Genetics, 35430 Urla, Izmir, Turkey.
Abstract:
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.
Related Concept Videos
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
Replicative Cell Senescence
Replicative Cell Senescence
Mitochondria
Sulfur Assimilation

