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Updated: Jun 8, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Staphylococcus intermedius is not only a zoonotic pathogen, but may also cause skin abscesses in humans after
Theodoros Kelesidis1, Sotirios Tsiodras
1Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA. tkelesid@gmail.com
Background:
Staphylococcus intermedius is a very rare human pathogen. There are only 16 cases in the literature that have described S. intermedius as a cause of infection in humans. Most of these cases have been described in association with exposure to animals, mostly dogs. However, this pathogen can cause infection in healthy individuals even without exposure to animals.
Methods:
All previous cases of S. intermedius infection included in our literature review were found using a PubMed search (1960-November 2009) of the English-language medical literature applying the terms 'Staphylococcus intermedius', 'abscess', 'infection', 'humans'. The references cited in these articles were examined to identify additional reports.
Results:
We describe the first case of skin abscesses caused by S. intermedius in an immunocompetent patient who used intravenous cocaine after coating his syringes with his saliva. We also summarize the literature regarding infections caused by S. intermedius in humans.
Conclusions:
This case illustrates for the first time that S. intermedius can cause skin abscesses in humans after direct inoculation of this pathogen into the skin and soft tissues. Clinicians should be aware of the fact that although the vast majority of infections from coagulase-positive Staphylococcus infections are secondary to Staphylococcus aureus, S. intermedius is also a potential pathogen in humans.
Insights
Staphylococcus intermedius, a rare bacterium, can cause skin abscesses in humans through direct inoculation, even in healthy individuals. This highlights its potential as a pathogen beyond animal exposure.
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Staphylococcus intermedius is an uncommon human pathogen, with limited documented cases.
- Most reported infections are linked to animal (primarily dog) contact.
- However, S. intermedius can infect humans irrespective of animal exposure.
Observation:
- A case of skin abscesses caused by S. intermedius in an immunocompetent patient is presented.
- The patient used intravenous cocaine, coating syringes with saliva, leading to direct pathogen inoculation.
- This represents the first documented instance of S. intermedius causing skin abscesses via this route.
Findings:
- S. intermedius can cause skin and soft tissue infections in humans.
- Direct inoculation of the pathogen into tissues is a viable transmission route.
- This bacterium is a potential human pathogen, not solely associated with animal reservoirs.
Implications:
- Clinicians should consider S. intermedius as a cause of Staphylococcus infections, particularly skin abscesses.
- Awareness of S. intermedius as a human pathogen is crucial, even when Staphylococcus aureus is more common.
- This finding expands the understanding of S. intermedius pathogenesis in humans.
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