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Inhibition of protein kinase C activation by low concentrations of aluminium
M Cochran1, D C Elliott, P Brennan
1School of Medicine, Flinders, University of South Australia, Bedford Park.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 24, 1990
Abstract:
An extract of rat brain protein kinase C was fully activated at a total calcium concentration 3 x 10(-4) mol/l (Ca2+ 10(-4) mol/l) in the presence of non-limiting concentrations of phosphatidylserine. Available aluminium (ionised plus soluble hydrolysed) at a median value of 2 x 10(-8) mol/l inhibited enzyme activation by 90% at this non-limiting calcium concentration. Literature values for tissue aluminium concentrations suggest that interference with this key intracellular regulatory protein might occur in vivo.