Related Experiment Video
Updated: Jun 8, 2026
10:28
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Metastatic lymph node targeted chemosensitivity test for gastric cancer
You-Jin Jang1, Jong-Han Kim, Sung-Soo Park
1Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
The Journal of Surgical Research
|October 12, 2010
Summary
Chemosensitivity testing revealed differences between primary gastric tumors and metastatic lymph nodes. This suggests personalized chemotherapy selection is crucial for effective adjuvant treatment in gastric adenocarcinoma patients.
Area of Science:
- Oncology
- Medical Research
Background:
- Gastric adenocarcinoma often involves lymph node metastasis.
- Understanding chemosensitivity differences between primary and metastatic sites is critical for treatment planning.
Purpose of the Study:
- To compare the chemosensitivity of primary gastric tumors and their corresponding metastatic lymph nodes.
- To evaluate the utility of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA) in assessing these differences.
Main Methods:
- Studied 26 gastric cancer patients with lymph node metastasis.
- Utilized adenosine triphosphate-based chemotherapy response assay (ATP-CRA) to assess chemosensitivity of primary tumors and metastatic lymph nodes.
- Analyzed inhibition rates for common chemotherapeutic agents (5-fluorouracil, cisplatin, doxorubicin, oxaliplatin).
Main Results:
- The ATP-CRA test showed a concordance rate of 30.8% between primary tumors and metastatic lymph nodes.
- Metastatic tumors exhibited higher inhibition rates with several agents compared to primary tumors.
- Significant differences in tumor inhibition rates were observed with doxorubicin (P=0.021) and correlations were found with cisplatin (P<0.001) and doxorubicin (P=0.031).
Conclusions:
- Chemosensitivity profiles differ between primary gastric tumors and metastatic lymph nodes.
- Careful selection of chemotherapeutic agents for adjuvant therapy, guided by chemosensitivity testing, is recommended.
- ATP-CRA may aid in tailoring treatment strategies for gastric cancer patients with lymph node metastasis.
