Related Experiment Video
Updated: Jun 8, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Bupropion SR and contingency management for adolescent smoking cessation
Kevin M Gray1, Matthew J Carpenter, Nathaniel L Baker
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA. graykm@musc.edu
None:
There is a significant need for evidence-based treatments for adolescent smoking cessation. Prior research, although limited, has suggested potential roles for bupropion sustained-release (SR) and contingency management (CM), but no previous studies have assessed their combined effect. In a double-blind, placebo-controlled design, 134 adolescent smokers were randomized to receive a 6-week course of bupropion SR + CM, bupropion SR + non-CM, placebo + CM, or placebo + non-CM, with final follow-up at 12 weeks. The primary outcome was 7-day cotinine-verified point prevalence abstinence, allowing for a 2-week grace period. Combined bupropion SR + CM treatment yielded significantly superior abstinence rates during active treatment when compared with placebo + non-CM treatment. In addition, combined treatment showed greater efficacy at multiple time points than did either bupropion SR + non-CM or placebo + CM treatment. Combined bupropion SR and CM appears efficacious, at least in the short-term, for adolescent smoking cessation and may be superior to either intervention alone.
Related Concept Videos
Antidepressant Drugs: MAOIs and Other Agents
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Operant Conditioning Intervention
In operant conditioning, behaviors that are...
Behavior Modification
A real-world application of operant conditioning principles is applied...
Oral Drug Delivery Systems: Continuous-Release Systems
COPD: Management Using Bronchodilators and Corticosteroids