Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Phase 2 Randomized Trial of Mezagitamab in Primary Immune Thrombocytopenia.

The New England journal of medicine·2026
Same author

Mosunetuzumab plus Pola-CHP compared with Pola-R-CHP in previously untreated DLBCL: final results from a phase 2 study.

Blood advances·2025
Same author

Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study.

Blood advances·2023
Same author

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial.

The Lancet. Haematology·2019
Same author

A Critical Evaluation of Enoxaparin Dose Adjustment Guidelines in Children.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2019
Same author

PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.

Thrombosis and haemostasis·2019

Related Experiment Video

Updated: Jun 8, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Rare bleeding disorders in young women.

Lakshmi Venkateswaran1, Donald L Yee

  • 1Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA. lxvenkat@txccc.org

Journal of Pediatric and Adolescent Gynecology
|October 12, 2010
PubMed
Summary

Rare bleeding disorders in children, including clotting factor deficiencies and vascular anomalies, cause significant bleeding. Understanding their presentation, diagnosis, and treatment is key for effective management.

Related Experiment Videos

Last Updated: Jun 8, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

Area of Science:

  • Pediatric Hematology
  • Hemostasis and Thrombosis

Background:

  • Rare bleeding disorders (RBDs) encompass rare clotting factor deficiencies and fibrinolytic pathway defects.
  • Vascular anomalies are also significant causes of recurrent bleeding in pediatric populations.
  • Menorrhagia is a common manifestation of these conditions in adolescents.

Purpose of the Study:

  • To provide an overview of infrequently encountered rare bleeding disorders in children and adolescents.
  • To discuss the clinical presentation, diagnostic work-up, and therapeutic options for these disorders.
  • To offer guidelines for the recognition and management of pediatric patients with rare bleeding conditions.

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on rare bleeding disorders.
  • Focuses on screening tests and therapeutic approaches.

Main Results:

  • Rare bleeding disorders present with significant bleeding, including menorrhagia.
  • Diagnosis relies on recognizing clinical signs and utilizing suggested screening tests.
  • Effective management requires a structured approach to diagnosis and therapy.

Conclusions:

  • Accurate diagnosis and optimal management of rare bleeding disorders are crucial for affected children and adolescents.
  • Knowledge of these disorders aids in timely recognition and intervention.
  • This review provides a foundation for approaching the diagnosis and therapy of rare bleeding conditions.