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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor
Mario Gössl1, Ulrike I Mödder, Rajiv Gulati
1Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA.
European Heart Journal
|October 12, 2010
Summary
Early coronary atherosclerosis is linked to the retention of osteogenic endothelial progenitor cells (EPCs) in the coronary circulation, suggesting a shift from repair to calcification.
Area of Science:
- Cardiovascular Biology
- Vascular Medicine
- Cellular Biology
Background:
- Endothelial progenitor cells (EPCs) are crucial for repairing injured coronary endothelium.
- Osteocalcin-positive EPCs (OCN+ EPCs) are elevated in coronary atherosclerosis.
- Early coronary atherosclerosis may involve the retention of osteogenic EPCs.
Purpose of the Study:
- To test if early coronary atherosclerosis is associated with the retention of osteogenic EPCs in the coronary circulation.
- To investigate the role of OCN+ EPCs in the progression of coronary atherosclerosis.
- To explore the relationship between EPC retention and endothelial dysfunction.
Main Methods:
- Blood samples collected from the aorta and coronary sinus of patients undergoing coronary endothelial function testing.
- Flow cytometry used to analyze EPC markers (CD133, CD34, KDR) and osteocalcin (OCN) in peripheral blood mononuclear cells.
- Calculation of net EPC gradient to determine retention, alongside analysis of SDF-1 alpha and IL-8 levels.
Main Results:
- Patients with endothelial dysfunction (ED) showed significant net retention of CD34+/CD133-/KDR+/OCN+ EPCs compared to controls.
- Retention of OCN+ EPCs correlated with the severity of endothelial dysfunction.
- Patients with ED also exhibited net retention of CD34+/CD133-/KDR+ EPCs and increased net production of IL-8.
Conclusions:
- Early coronary atherosclerosis is characterized by the retention of OCN+ EPCs in the coronary circulation.
- This retention may promote progressive coronary calcification instead of normal vascular repair.
- Osteogenic EPCs play a significant role in the pathophysiology of early coronary atherosclerosis.
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