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Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation

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Structure and function in patients with glaucomatous defects near fixation.

Asifa Shafi¹, William H Swanson, Mitchell W Dul

¹Graduate Center for Vision Research, SUNY State College of Optometry, New York, New York, USA.

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|October 12, 2010

Summary

High-resolution perimetry confirms a linear relationship between visual field sensitivity and temporal neuroretinal rim area in glaucoma patients. Agreement between these measures aligns with normal variability, aiding in glaucoma assessment.

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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

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Published on: March 12, 2016

Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Glaucoma is a progressive optic neuropathy characterized by visual field loss.
Assessing the relationship between visual function and structural damage is crucial for glaucoma management.
Early glaucomatous defects often occur within 10° of fixation.

Purpose of the Study:

To evaluate the correlation between perimetric sensitivity and neuroretinal rim area.
To assess agreement between these measures using high-resolution mapping in glaucoma patients with paracentral defects.

Main Methods:

31 open-angle glaucoma patients and 110 controls were included.
Perimetric sensitivity was measured using Humphrey Field Analyzer (HFA) II-i with 10-2 SITA standard algorithm.
Temporal neuroretinal rim area was quantified using Heidelberg Retina Tomograph 3.

Main Results:

A moderate correlation (r² >30%, p < 0.005) was found between contrast sensitivity and temporal rim area.
Bland-Altman analysis demonstrated good agreement between perimetric sensitivity and rim area.
Agreement limits were consistent with normal between-subject variability.

Conclusions:

High-resolution perimetry confirms linear relationships between visual sensitivity and temporal neuroretinal rim area.
The agreement between these measures in glaucoma patients is comparable to normal variability.
These findings support the use of high-resolution mapping for glaucoma assessment.