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Updated: Jun 8, 2026
Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
Published on: April 16, 2016
Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped
Raimo Silvennoinen1, Stanislav Hasoň, Vladimír Vetterl
1Department of Physics and Mathematics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland. raimo.silvennoinen@uef.fi
Abstract:
Adsorption of the elongated human plasma fibrinogen (HPF) and globular human serum albumin molecules on a titanium-based surface is monitored by analyzing permittivity and optical roughness of protein-modified surfaces by using a diffractive optical element (DOE)-based sensor and variable angle spectro-ellipsometry (VASE). Both DOE and VASE confirmed that fibrinogen forms a thicker and more packed surface adlayer compared to a more porous and weakly adsorbed albumin adlayer. A linear relation of the permittivity (ε(')) and dielectric loss (ε('')) was found for some of the dry titanium-doped hydrocarbon (TDHC) surfaces with excellent HPF adsorption ability. We discuss some aspects of TDHC's aging and its possible effects on fibrinogen adsorption.
