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Updated: Jun 8, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
Fluorine-18 chemistry in micro-reactors
Shuiyu Lu1, Joong-Hyun Chun, Victor W Pike
1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Room B3 C346, Bethesda, MD 20892-1003, USA.
Abstract:
Recent applications of micro-reactor (microfluidics) technology to radiofluorination chemistry within our laboratory are presented, based on use of either a simple T-shaped glass micro-reactor or a more advanced microfluidics instrument. The topics include reaction optimization and radioligand production, in particular the study of the radiofluorination of diaryliodonium salts, [(18)F]fluoride ion exchange with xenon difluoride(,) esterification with [(18)F]2-fluoroethyl tosylate, and the syntheses of [(18)F]fallypride, [(18)F]FBR and [(18)F]SL702 from [(18)F]fluoride ion.
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