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Updated: Jan 25, 2026

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
Peroxisome proliferator-activated receptor alpha target genes
Maryam Rakhshandehroo1, Bianca Knoch, Michael Müller
1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands.
Peroxisome proliferator-activated receptor alpha (PPARα) regulates lipid metabolism and energy homeostasis. This review details PPARα target genes, focusing on liver gene regulation for insights into its broad biological functions.
Area of Science:
- Molecular Biology
- Metabolic Regulation
- Gene Transcription
Background:
- Peroxisome proliferator-activated receptor alpha (PPARα) is a key transcription factor.
- PPARα regulates inflammation, immunity, nutrient metabolism, and energy homeostasis.
- It is activated by fatty acids and targeted by fibrate drugs.
Purpose of the Study:
- To provide an overview of PPARα's role in lipid metabolism and other pathways.
- To analyze known and putative PPARα target genes.
- To emphasize PPARα's gene regulation in the liver.
Main Methods:
- Literature review and analysis of PPARα target genes.
- Examination of gene expression regulation by PPARα.
- Focus on hepatic gene regulation.
Main Results:
- PPARα influences a wide array of biological processes through target gene expression.
- Fatty acids and fibrates are key activators of PPARα.
- Analysis reveals specific PPARα target genes involved in metabolic pathways.
Conclusions:
- PPARα plays a crucial role in metabolic regulation, particularly lipid metabolism.
- Understanding PPARα target genes is essential for elucidating its functions.
- Findings on hepatic PPARα regulation have broader implications for other tissues.
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