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Updated: Jun 8, 2026
12:31
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Convenient route to water-sensitive sol-gel precursors using click chemistry
Nirmalya Moitra1, Joël J E Moreau, Xavier Cattoën
1Institut Charles Gerhardt Montpellier (UMR 5253 CNRS-UM2-ENSCM-UM1), Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'école normale, 34296 Montpellier, France.
Chemical Communications (Cambridge, England)
|October 12, 2010
Abstract:
The CuAAC-'click' reaction under anhydrous conditions is reported as a new tool for the preparation of moisture-sensitive triethoxysilyl compounds that are obtained in 5 minutes in excellent yield with simple purification.
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The acid-catalyzed addition of water to the double bond of alkenes is a large-scale industrial method used to synthesize low-molecular-weight alcohols. An acidic atmosphere is required to allow the hydrogen in the water molecule to act as an electrophile and attack the double bond in an alkene. The addition of a proton to the double bond creates a carbocation intermediate. The proton preferentially bonds to the less substituted end of the double bond to create a more stable carbocation...
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