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Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK

Qiaoyi Zhang1, Stephanie D Taylor, Vasilisa Sazonov

  • 1Global Health Outcomes, Merck & Co., Inc., Whitehouse Station, NJ, USA.

Primary Care Respiratory Journal : Journal of the General Practice Airways Group
|October 12, 2010
PubMed

Insights

Persistence with inhaled corticosteroid (ICS) therapy is poor for children with persistent asthma. Over half of children discontinued their initial ICS prescription within one year.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacotherapy Adherence
  • Asthma Management

Background:

  • Adherence to asthma controller medications declines over time.
  • Poor persistence with long-term asthma therapy is a recognized challenge.

Purpose of the Study:

  • To assess persistence with inhaled corticosteroid (ICS) therapy in children with persistent asthma.
  • To evaluate one-year treatment persistence after initiating ICS for pediatric asthma.

Main Methods:

  • A primary care database study analyzed children aged 2-14 years with persistent asthma.
  • Persistence was evaluated over one year following the first ICS prescription.
  • Discontinuation was defined as no ICS prescription in the final three months of follow-up.

Main Results:

  • Of 7375 children, 2220 had persistent asthma and initiated ICS.
  • Only 33.6% of children continued their initial ICS therapy for the full year.
  • A significant 53.7% of children discontinued ICS therapy within one year.

Conclusions:

  • Persistence with initial inhaled corticosteroid (ICS) monotherapy is notably poor in children diagnosed with persistent asthma.
  • Findings highlight a critical need for interventions to improve long-term adherence to asthma controller medications in pediatric populations.
Abstract

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