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Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling
1Dept of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand.
Fundamental & Clinical Pharmacology
|January 1, 1990
Abstract:
The combined application of pharmacokinetic and pharmacodynamic models to concentration and effect observations can be used to predict the consequences of alternative dosing strategies. Efficient experimental design is intimately related to the models that may be employed for data analysis. This is especially important in phase I studies which provide the basis for decisions on future clinical trials.