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Related Experiment Video

Updated: Jun 8, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Cigarette smoking in patients with systemic sclerosis.

Marie Hudson¹, Ernest Lo, Ying Lu

¹SMBD-Jewish General Hospital and McGill University, Montreal, Quebec, Canada. marie.hudson@mcgill.ca

Arthritis and Rheumatism

|October 12, 2010

Summary

Cigarette smoking significantly harms vascular, gastrointestinal, and respiratory health in systemic sclerosis (SSc) patients. Smoking cessation is recommended to improve outcomes and reduce symptom severity.

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Area of Science:

Rheumatology
Pulmonology
Cardiology

Background:

Systemic sclerosis (SSc) is a complex autoimmune disease affecting connective tissues.
The impact of cigarette smoking on SSc patient outcomes requires further elucidation.
Understanding smoking's role is crucial for managing SSc complications.

Purpose of the Study:

To investigate the association between cigarette smoking and vascular, gastrointestinal, and respiratory outcomes in patients with systemic sclerosis (SSc).

Main Methods:

Analysis of 606 patients from the Canadian Scleroderma Research Group cohort.
Smoking history assessed via self-report and modeled using categorical variables and the Comprehensive Smoking Index (CSI).
Multiple regression models adjusted for age, sex, disease duration, and disease subtype (limited/diffuse).

Main Results:

Smoking demonstrated a significant negative impact on most vascular, gastrointestinal, and respiratory outcomes in SSc patients.
Long-lasting effects observed, including persistent respiratory abnormalities.
Smoking cessation showed potential benefits, such as reduced severity of Raynaud's phenomenon.

Conclusions:

Physicians should strongly advise SSc patients to cease smoking.
Increased availability of smoking cessation resources for SSc patients is essential.
Prioritizing smoking cessation can improve patient prognosis and quality of life.