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Related Experiment Videos

Liver dysfunction in severe birth asphyxia.

A Saili1, M S Sarna, G Gathwala

  • 1Neonatal Unit, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi.

Indian Pediatrics
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

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Severe birth asphyxia in newborns can impair liver function, with deranged liver tests correlating to higher mortality rates. Higher transaminase and alkaline phosphatase levels indicate a poorer prognosis for survival in these infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Biochemistry

Background:

  • Birth asphyxia is a significant cause of neonatal mortality and morbidity.
  • Liver dysfunction is a potential complication of severe birth asphyxia.
  • Understanding the impact of asphyxia on liver function is crucial for predicting outcomes.

Purpose of the Study:

  • To investigate the prevalence of liver function derangements in neonates with severe birth asphyxia.
  • To determine the correlation between deranged liver function tests and mortality in this population.
  • To compare serum liver enzyme levels between survivors and non-survivors.

Main Methods:

  • A cohort of 46 full-term, appropriate-for-gestational-age neonates was studied.
  • The study included 31 infants with severe birth asphyxia and 15 healthy controls.

Related Experiment Videos

  • Liver function tests (serum transaminases [SGOT, SGPT], alkaline phosphatase) were analyzed.

    • Main Results:

    • Liver function tests were deranged in 64.52% of asphyxiated neonates.
    • Mortality rate was 60% among asphyxiated infants with deranged liver function.
    • Serum SGOT, SGPT, and alkaline phosphatase levels were significantly higher in non-survivors compared to survivors.

    Conclusions:

    • Severe birth asphyxia frequently leads to liver function abnormalities in neonates.
    • Deranged liver function tests in asphyxiated newborns are associated with increased mortality.
    • Elevated serum transaminases and alkaline phosphatase are indicators of poor prognosis in birth asphyxia.