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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jun 8, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Disorders of bone remodeling.

Xu Feng1, Jay M McDonald

  • 1Department of Pathology, Center for Metabolic Bone Disease, The University of Alabama at Birmingham, 35294-0007, USA. xufeng@uab.edu

Annual Review of Pathology
|October 13, 2010
PubMed
Summary

Bone remodeling, essential for skeletal health, involves osteoclast-driven resorption and osteoblast-driven formation. Disruptions to this balance cause bone diseases in men and women.

Area of Science:

  • Skeletal Biology
  • Bone Physiology
  • Pathophysiology

Background:

  • The skeleton provides structural support, organ protection, and mineral homeostasis.
  • Continuous bone modeling is vital for lifelong skeletal function.
  • Bone remodeling balances bone resorption by osteoclasts and bone formation by osteoblasts.

Purpose of the Study:

  • To review major bone remodeling diseases.
  • To emphasize current understanding of pathophysiological mechanisms.
  • To highlight factors disrupting bone remodeling.

Main Methods:

  • Literature review of bone remodeling diseases.
  • Analysis of pathophysiological mechanisms.
  • Emphasis on factors affecting bone remodeling.

More Related Videos

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

Related Experiment Videos

Last Updated: Jun 8, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

Main Results:

  • Bone remodeling requires tight coupling of resorption and formation.
  • Disruptions can lead to altered bone mass or quality.
  • Factors include hormonal changes, aging, physical activity, drugs, and diseases.

Conclusions:

  • Bone remodeling is a complex physiological process.
  • Imbalances lead to significant bone disorders.
  • Understanding mechanisms is key to managing bone diseases.