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Published on: November 2, 2014
Mouse models of cancer
Dong-Joo Cheon1, Sandra Orsulic
1Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Annual Review of Pathology
|October 13, 2010
Summary
Genetically engineered mouse models advance cancer biology research by validating genes and aiding therapeutic testing. However, limitations in accurately modeling human tumors necessitate further development for clinical relevance.
Area of Science:
- Oncology
- Genetics
- Translational Medicine
Background:
- Genetically engineered mouse models (GEMMs) are crucial tools in cancer research.
- They aid in understanding gene function, biomarker discovery, and tumorigenesis mechanisms.
Purpose of the Study:
- To review the contributions of GEMMs to cancer biology.
- To identify limitations and future challenges in developing clinically relevant mouse models.
Main Methods:
- Literature review of studies utilizing GEMMs in cancer research.
- Analysis of the strengths and weaknesses of current mouse models.
Main Results:
- GEMMs have significantly advanced cancer biology understanding and therapeutic strategy testing.
- Key limitations include species-specific differences and inadequate recapitulation of human tumor development.
Conclusions:
- GEMMs are invaluable but require further refinement for accurate human cancer modeling.
- Future efforts should focus on generating models that mirror human cancer's molecular, cellular, and genomic complexity and clinical responses.
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