Related Experiment Videos
The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients
A Dmoszyńska-Giannopoulou1, L Janicka, B Sokołowska
1Department of Haematology and Nephrology, Medical School, Lublin, Poland.
International Urology and Nephrology
|January 1, 1990
Abstract:
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.