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Prolactin secretion in kidney transplant patients
W Grzeszczak1, F Kokot, A Wiecek
1Department of Nephrology, Silesian School of Medicine, Katowice, Poland.
International Urology and Nephrology
|January 1, 1990
Summary
Kidney transplant patients exhibit normal baseline prolactin levels but an exaggerated prolactin secretion response to chlorpromazine, unlike healthy individuals. Immunosuppressive therapy type did not affect these prolactin levels.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Kidney transplant recipients (KTP) often experience endocrine alterations.
- Prolactin (PRL) regulation may be affected by kidney function and immunosuppressive drugs.
Purpose of the Study:
- To investigate plasma prolactin levels in male kidney transplant patients.
- To compare prolactin response to inhibitory and stimulatory agents in KTP versus healthy controls.
Main Methods:
- Plasma prolactin levels were measured in 27 male KTP and 12 healthy males.
- Measurements were taken under baseline, alpha-bromocriptine (inhibitory), and chlorpromazine (stimulatory) conditions.
Main Results:
- KTP showed normal baseline prolactin and normal response to alpha-bromocriptine.
- Chlorpromazine administration induced an exaggerated prolactin secretion in KTP compared to controls.
- Neither cyclosporine A nor azathioprine significantly altered prolactin profiles.
Conclusions:
- Kidney transplantation may alter prolactin regulation, specifically blunting inhibitory responses and exaggerating stimulatory responses.
- The type of immunosuppression used did not appear to influence prolactin secretion patterns in KTP.