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Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

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Related Experiment Video

Updated: Jun 8, 2026

A Novel Application of Musculoskeletal Ultrasound Imaging
10:53

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Published on: September 17, 2013

Explaining functioning outcomes across musculoskeletal conditions: a multilevel modelling approach.

Alarcos Cieza1, Cristina Bostan, Cornelia Oberhauser

  • 1Institute for Health and Rehabilitation Sciences, Research Unit for Biopsychosocial Health, Ludwig-Maximilians-Universität, Munich, Germany. alarcos.cieza@lmu.de

Disability and Rehabilitation
|October 13, 2010
PubMed
Summary

Changes in health outcomes for musculoskeletal conditions are linked to specific physical functioning and environmental factors. Identifying these key areas helps target interventions for chronic pain management.

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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Published on: April 11, 2018

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Last Updated: Jun 8, 2026

A Novel Application of Musculoskeletal Ultrasound Imaging
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Published on: September 17, 2013

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Area of Science:

  • Rehabilitation medicine
  • Health outcomes research
  • Chronic pain management

Background:

  • Musculoskeletal conditions (MSCs) significantly impact daily life and health outcomes.
  • Understanding the interplay between functioning domains and environmental factors is crucial for effective management.
  • Existing research often lacks a comprehensive view of these interconnected elements in diverse MSCs.

Purpose of the Study:

  • To investigate the relationship between changes in health outcomes and alterations in functioning domains and environmental factors within musculoskeletal conditions.
  • To identify specific International Classification of Functioning, Disability and Health (ICF) categories that explain variability and change in patient health over time.
  • To determine common intervention targets across various chronic painful musculoskeletal conditions.

Main Methods:

  • A longitudinal observational study involving 291 patients with conditions including low back pain, osteoarthritis, osteoporosis, rheumatoid arthritis, and chronic widespread pain.
  • Data collected at baseline, 4, and 8 weeks using ICF Core Sets tailored for specific musculoskeletal conditions.
  • Multilevel models for change were employed to analyze the impact of ICF categories on SF-36 general, physical, and mental health scores.

Main Results:

  • Health outcomes showed minor fluctuations, primarily associated with locomotor functions (e.g., muscle power) and related activities/participation (e.g., lifting/carrying).
  • A significant portion of the baseline variance in health outcomes was explained by a limited set of ICF functioning categories.
  • The study identified specific functioning problems and environmental factors relevant to the experience of chronic pain.

Conclusions:

  • The identified functioning problems and environmental factors provide a framework for understanding patterns and variations in living with chronic painful conditions.
  • These factors represent common intervention targets applicable across a spectrum of musculoskeletal conditions.
  • This research contributes to a more holistic approach to managing chronic pain by highlighting key areas for therapeutic focus.