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Updated: Jun 8, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Review article: gene therapy, recent developments and future prospects in gastrointestinal oncology
Y Touchefeu1, K J Harrington, J P Galmiche
1Institut des Maladies de l'Appareil Digestif, INSERM U, University Hospital, Nantes, France. yann.touchefeu@icr.ac.uk
Gene therapy shows promise for gastrointestinal cancers, with ongoing research into new genes and vectors. Clinical trials report encouraging results and good safety, suggesting a potential future treatment option.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gene therapy involves introducing genetic material for therapeutic purposes.
- Various gene therapy vectors are utilized in gastrointestinal oncology.
Purpose of the Study:
- To review recent developments in gene therapy for liver, colon, and pancreatic cancers.
- To analyze published clinical trials on gene therapy applications in these cancers.
Main Methods:
- Literature search conducted on the PubMed database.
- English-language publications were exclusively reviewed.
Main Results:
- Investigated therapeutic genes include tumor suppressor, suicide, antiangiogenesis, inflammatory cytokine, and micro-RNA genes.
- Progress noted in novel vectors like oncolytic viruses and synergistic combinations with chemotherapy and radiation.
- Phase I and II clinical trials demonstrate encouraging outcomes and favorable safety profiles for gene therapy strategies.
Conclusions:
- Gene therapy is not currently standard clinical practice for cancer treatment.
- Significant basic and clinical advancements position gene therapy as a promising therapeutic approach for gastrointestinal tumors.
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