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Review article: gene therapy, recent developments and future prospects in gastrointestinal oncology

Y Touchefeu1, K J Harrington, J P Galmiche

  • 1Institut des Maladies de l'Appareil Digestif, INSERM U, University Hospital, Nantes, France. yann.touchefeu@icr.ac.uk

Alimentary Pharmacology & Therapeutics
|October 13, 2010
PubMed
Abstract

Insights

Gene therapy shows promise for gastrointestinal cancers, with ongoing research into new genes and vectors. Clinical trials report encouraging results and good safety, suggesting a potential future treatment option.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy involves introducing genetic material for therapeutic purposes.
  • Various gene therapy vectors are utilized in gastrointestinal oncology.

Purpose of the Study:

  • To review recent developments in gene therapy for liver, colon, and pancreatic cancers.
  • To analyze published clinical trials on gene therapy applications in these cancers.

Main Methods:

  • Literature search conducted on the PubMed database.
  • English-language publications were exclusively reviewed.

Main Results:

  • Investigated therapeutic genes include tumor suppressor, suicide, antiangiogenesis, inflammatory cytokine, and micro-RNA genes.
  • Progress noted in novel vectors like oncolytic viruses and synergistic combinations with chemotherapy and radiation.
  • Phase I and II clinical trials demonstrate encouraging outcomes and favorable safety profiles for gene therapy strategies.

Conclusions:

  • Gene therapy is not currently standard clinical practice for cancer treatment.
  • Significant basic and clinical advancements position gene therapy as a promising therapeutic approach for gastrointestinal tumors.

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