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Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Tuberculosis

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Related Experiment Video

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Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray

Published on: April 25, 2014

Multi-recipient donor-transmitted tuberculosis.

J Edathodu¹, A Alrajhi, M Halim

¹Section of Infectious Diseases, Section of Microbiology, Department of Medicine, King Faisal Hospital & Research Centre, Riyadh, Saudi Arabia. jameelaedathodu@yahoo.com

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease

|October 13, 2010

Summary

Organ transplant recipients face significantly higher tuberculosis (TB) risks. This report details three cases of TB transmitted via organ transplantation from a single donor, highlighting a rare but serious transmission route.

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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

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Last Updated: Jun 8, 2026

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Area of Science:

Infectious Diseases
Transplantation Medicine
Immunology

Background:

Tuberculosis (TB) incidence is markedly elevated in organ transplant recipients, estimated at 20-74 times higher than in the general population.
Mortality rates associated with TB in this vulnerable group can reach up to 30%, underscoring the severity of the condition.
The primary cause of TB in transplant patients is typically the reactivation of latent infection due to post-transplant immunosuppression.

Observation:

Donor-transmitted TB through organ transplantation is considered an infrequent occurrence.
This report presents a series of three distinct cases where tuberculosis was transmitted from a single organ donor to multiple recipients.
The observed transmission highlights a critical, albeit rare, pathway for infectious disease spread in the context of organ donation.

Findings:

The study identifies a single donor as the source of tuberculosis infection in three separate organ transplant recipients.
This finding challenges the perception of donor-transmitted TB as extremely rare, demonstrating its potential impact.
Analysis of these cases provides crucial insights into the epidemiology of TB transmission in transplantation.

Implications:

These findings necessitate a re-evaluation of donor screening protocols for tuberculosis, particularly for latent infection.
Enhanced vigilance and diagnostic strategies are crucial to prevent donor-derived TB transmission in organ transplantation.
Implementing stricter screening measures could significantly reduce the incidence and mortality of TB in transplant recipients.