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Updated: Jun 8, 2026
Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
[A study on the allelic deletion of nm23 genes in human lung cancer.]
1Department of Thoracocardiac Surgery , The First University Hospital , West China University of Medical Sciences , Chengdu 610041 , P. R. China.
Background:
To explore the role of allelic deletions of nm23 genes in human lung cancer.
Methods:
Allelic deletions of nm23 genes were detected in 52 lung cancer tissue samples and their corresponding normal tissues as control by Southern blotting.
Results:
Loss of heterozygosity (LOH) of nm23-H1 gene was found in 14 out of 52 informative lung cancers , with a LOH rate of 26. 92 %; 2 of the 47 informative lung cancer tissues existed allelic deletion of nm23-H2 gene , with a allelic deletion rate of 4. 26 %. The LOH rate of nm23-H1 gene in cancer with lymph node or distant metastasis (42. 86 %) was significantly higher than that in lung cancer without metastasis (8. 33 %) ( P < 0. 01) . nm23-H1 LOH rate was also remarkably higher in undifferentiated and poor differentiated cancer (45. 45 %) than in moderate to well differentiated cancer (13. 33 %) ( P < 0. 05) . No relationship was found among the allelic deletion of the nm23-H1 and histoclassification of the tumor , P-TNM stages , size of the primary tumor , location of the cancer , and age of the patients ( P > 0. 05) .
Conclusions:
nm23 gene may be involved in the differentiation and metastasis of human lung cancer , and nm23-H1 gene may play a more important role in the regulation of cell differentiation and metastasis of lung cancer than nm23-H2 gene.