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Published on: August 24, 2019
Infectious causes of appendicitis
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. lampslauraw@uams.edu
Abstract:
The pathologic spectrum of the inflamed appendix encompasses a wide range of infectious entities, some with specific histologic findings, and others with nonspecific findings that may require an extensive diagnostic evaluation. The appendix is exclusively involved in some of these disorders, and in others may be involved through extension from other areas of the gastrointestinal tract. This review discusses the pathologic features of bacterial, viral, fungal, and parasitic infections affecting the appendix, including adenovirus; cytomegalovirus; Yersinia, Actinomyces, Mycobacterium, or Histoplasma species; Enterobius vermicularis; schistosomiasis; and Strongyloides stercoralis. Pertinent ancillary diagnostic techniques and the clinical context and significance of the various infections are also discussed.
Insights
This review explores infectious appendicitis, covering bacterial, viral, fungal, and parasitic causes. It details pathologic features and diagnostic methods for these diverse appendix infections.
Area of Science:
- Gastroenterology
- Pathology
- Infectious Diseases
Background:
- Inflamed appendix pathology involves diverse infectious entities.
- Appendix involvement can be primary or secondary to gastrointestinal spread.
- Diagnosis may require extensive evaluation due to nonspecific findings.
Purpose of the Study:
- To review the pathologic features of infectious agents affecting the appendix.
- To discuss diagnostic techniques and clinical significance of appendiceal infections.
Main Methods:
- Literature review of infectious diseases impacting the appendix.
- Analysis of pathologic and histologic findings.
- Discussion of clinical context and diagnostic approaches.
Main Results:
- Identified bacterial, viral, fungal, and parasitic infections of the appendix.
- Detailed specific pathogens like adenovirus, cytomegalovirus, Yersinia, Actinomyces, Mycobacterium, Histoplasma, Enterobius vermicularis, Schistosomiasis, and Strongyloides stercoralis.
- Highlighted diagnostic challenges and ancillary techniques.
Conclusions:
- Infectious appendicitis presents a broad spectrum of pathologic findings.
- Understanding diverse pathogens is crucial for accurate diagnosis and management.
- Ancillary diagnostic methods aid in identifying specific infectious causes.
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