[Obstetrical approach in prenatal diagnosis in the first and second trimester of pregnancy]

From 712 women-patients in Genetic Consultation Department 284 of them were submitted to antenatal diagnostics. The most common indications were old age of pregnant women or a malformed child in the previous pregnancies or in the family. Horion biopsy was done in 118 patients and amniocentesis was performed in the I and II trimester of pregnancy in 188 of them. The fetal loss according to the weeks of pregnancy in the groups, where was done the antenatal diagnostic treatment was not significantly different from horion biopsy was 1.9% and the success of cultivating of horion tissue was 98%. The findings of chromosome analysis were confirmed in all cases.