A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the bla(OXA-23) gene and disrupting the outer
Yangsoon Lee1, Chang-Ki Kim, Hyukmin Lee
1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Abstract:
We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the bla(OXA-23) gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the bla(OXA-23) gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
Antibiotic Selection
Clinical Significance of Antibiotic Resistance
Genome Size and the Evolution of New Genes
CRISPR and crRNAs
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...

