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Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
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Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assembly

Hao Xu1, William Wickner

  • 1Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755-3844, USA.

The Journal of Biological Chemistry
|October 13, 2010
PubMed
Summary

Phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) play distinct, asymmetric roles in SNARE-mediated membrane fusion. These phosphoinositides are crucial for organelle fusion, with PI(3)P and PI(4,5)P(2) regulating specific steps and synergistic interactions.

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