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Updated: Jun 8, 2026

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
Published on: December 30, 2025
Superficial siderosis of the central nervous system due to bilateral jugular vein thrombosis
Dileep R Yavagal1, Deqing Geng, Serra Akar
1Department of Neurosciences, Rebecca and John Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093-0819, USA.
Objective:
To describe a novel cause of meningeal siderosis due to intermittent subarachnoid bleeding caused by chronic bilateral jugular vein thrombosis.
Design:
Case report and review of literature.
Patient:
A 51-year-old man with a distant history of cervical injury who presented with transient aphasia in the setting of progressive cognitive decline.
Intervention:
Neurological examination, magnetic resonance imaging, lumbar puncture, and angiogram.
Results:
The patient had intermittent subarachnoid bleeding resulting from extensive venous collaterals in the neck and cervical spine due to chronic bilateral jugular vein thrombosis.
Conclusion:
Unexplained neurological deterioration and history of cervical trauma warrants diagnostic consideration of superficial siderosis and jugular vein thrombosis.
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