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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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Related Experiment Video

Updated: Jun 8, 2026

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
06:58

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Published on: August 17, 2017

Bone fragility in men: where are we?

R Nuti1, D Merlotti, C M Francucci

  • 1Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Viale Bracci 1, Siena, Italy. nutir@unisi.it

Journal of Endocrinological Investigation
|October 13, 2010
PubMed
Summary

Osteoporosis affects one in three fractures in men, often with severe consequences. This review highlights recent advances in understanding and treating male osteoporosis, which is under-recognized and undertreated.

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Transverse Fracture of the Mouse Femur with Stabilizing Pin
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Related Experiment Videos

Last Updated: Jun 8, 2026

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
06:58

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Published on: August 17, 2017

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
08:36

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

Transverse Fracture of the Mouse Femur with Stabilizing Pin
03:57

Transverse Fracture of the Mouse Femur with Stabilizing Pin

Published on: December 29, 2021

Area of Science:

  • Orthopedics
  • Endocrinology
  • Geriatrics

Background:

  • Osteoporosis in men is a significant clinical concern, with approximately one-third of osteoporotic fractures occurring in males.
  • Fractures in men typically result in more severe outcomes compared to women.
  • Male osteoporosis is frequently underdiagnosed and inadequately managed, despite its prevalence and impact.

Purpose of the Study:

  • To summarize recent advancements in the understanding of osteoporosis in men.
  • To review the current knowledge on the causes and pathogenesis of male osteoporosis.
  • To provide an overview of contemporary treatment strategies for osteoporosis in men.

Main Methods:

  • This study is a review of recent developments in the field.
  • Literature search on causes, pathogenesis, and treatment of male osteoporosis.
  • Synthesis of current evidence and clinical findings.

Main Results:

  • Osteoporosis in men is a growing health issue with serious fracture consequences.
  • Despite its impact, male osteoporosis is often overlooked in clinical practice.
  • Recent research offers new insights into the disease's mechanisms and management.

Conclusions:

  • There is a critical need to improve the recognition and treatment of osteoporosis in men.
  • Understanding the specific causes and pathogenesis in men is crucial for effective management.
  • Advances in treatment strategies offer improved outcomes for men with osteoporosis.