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Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...

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Related Experiment Video

Updated: Jun 8, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

A new chemotaxis device for cell migration studies.

Waseem Khan Raja1, Bojana Gligorijevic, Jeff Wyckoff

  • 1College of Nanoscale Science and Engineering, University at Albany, SUNY, Albany, NY, USA.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|October 13, 2010
PubMed
Summary

Researchers developed NANIVID, a novel chemotaxis device for studying cell movement. This miniature, cost-effective tool enables precise control of growth factor gradients for cancer cell research in vitro and potentially in vivo.

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Last Updated: Jun 8, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Materials Science

Background:

  • Chemotaxis is crucial for understanding cell migration in biological processes.
  • Existing chemotaxis devices often lack miniaturization, cost-effectiveness, or precise gradient control.
  • Advanced nano/microfabrication techniques enable the creation of sophisticated cellular analysis tools.

Purpose of the Study:

  • To design and optimize a versatile, miniature chemotaxis device (NANIVID) for in vitro cell studies.
  • To establish a reliable method for generating stable chemical gradients using hydrogel-based reservoirs.
  • To evaluate the device's efficacy in studying breast cancer cell chemotaxis in 2D and 3D cultures.

Main Methods:

  • Fabrication of the NANIVID device using microphotolithography and polymer bonding of Pyrex substrates.
  • Incorporation of a hydrogel blend releasing Epidermal Growth Factor (EGF) from a micro-reservoir.
  • Characterization of the sustained release and gradient formation of EGF over several hours.
  • Testing the device with breast cancer cells in 2D and 3D cell culture models.

Main Results:

  • Successful fabrication of a compact (0.2 × 2 × 3 mm) and autonomous chemotaxis device.
  • Demonstration of sustained EGF release, creating a stable concentration gradient.
  • Validation of the device's utility in observing chemotaxis of breast cancer cells in various culture formats.
  • Preliminary evidence suggesting potential for in vivo applications.

Conclusions:

  • The NANIVID device offers a flexible, affordable, and miniature solution for chemotaxis research.
  • The device effectively generates stable chemical gradients essential for studying cell migration.
  • NANIVID shows promise for advancing breast cancer cell research and potentially other in vivo applications.